GSK321
GSK321 is a potent and selective mutant IDH1 inhibitor. It suppresses lipid synthesis and cell proliferation in OPA1-deficient MEFs, while also inhibiting cytoplasmic glutamine reductive carboxylation. This compound is a valuable research tool for studying metabolic dysregulation in cancers such as leukemia, applicable in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1816331-63-1
Product Name Alternative
IDH1, GSK 321, GSK321, GSK-321
Field of Research
Metabolism Research
Purity
99.73% (May vary between batches)
Solubility
DMSO:200 mg/mL (398.76 mM)
Smiles
C (N1C2=C (C (C (NC3=CC ([C@H] (C) O) =CC=C3) =O) =N1) CN (C (=O) C4=CC=CN4) C[C@H]2C) C5=CC=C (F) C=C5
Molecular Formula
C28H28FN5O3
Molecular Weight
501.55
Storage Conditions
-20°C
Notes
For research use only.
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