Sovleplenib
Sovleplenib (HMPL523) is a potent and selective oral inhibitor of spleen tyrosine kinase (SYK) with an IC50 of 25 nM. It demonstrates activity in preclinical models of immune thrombocytopenia (ITP) and is used in research investigating autoimmune and hematological disorders.
Product Specifications
CAS Number
1415792-84-5
Product Name Alternative
HMPL523, HMPL-523, HMPL 523, Syk, Sovleplenib
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.51% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.14 mM) ; DMSO:14.48 mg/mL (30 mM)
Smiles
CS (=O) (=O) N1CCC (CC1) c1ccc (cc1) -c1cc2nccnc2c (NC[C@@H]2CNCCO2) n1
Molecular Formula
C24H30N6O3S
Molecular Weight
482.6
Storage Conditions
-20°C
Notes
For research use only.
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