Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

Catalytic activity: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-. function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. PTM: The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8. similarity: Belongs to the peptidase C14A family. similarity: Contains 1 CARD domain. subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. tissue specificity: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.