Caspase 4 (p10, Cleaved-Ala290) rabbit pAb
Catalytic activity: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-. function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. PTM: The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8. similarity: Belongs to the peptidase C14A family. similarity: Contains 1 CARD domain. subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. tissue specificity: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
Product Specifications
Background
Synonyms
Caspase-4 (CASP-4;EC 3.4.22.57;ICE(rel)-II;Protease ICH-2;Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
Gene ID
837
UniProt
P49662
Cellular Locus
Host
Rabbit
Species Reactivity
Human
Reactivity
Human
Immunogen
Synthesized peptide derived from human Caspase 4 (p10, Cleaved-Ala290)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Molecular Weight
10 42kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES19956-1.pdf
Observed Molecular Weight
10 - 42 kD
Subcellular Location
Other Product Names
Caspase-4 (CASP-4; EC 3.4.22.57; ICE (rel) -II; Protease ICH-2; Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
Gene ID (Human)
837
SwissProt (Human)
P49662
Available Sizes
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