NSC 109555
NSC 109555 is a potent and selective ATP-competitive inhibitor of Chk2 (IC50 = 0.2 μM) with minimal activity against Chk1. It inhibits histone H1 phosphorylation and mitochondrial ATP synthesis, demonstrating antiproliferative effects in leukemia models both in vitro and in vivo.
Product Specifications
CAS Number
15427-93-7
Field of Research
Cell Biology, Neuroscience
Smiles
CS (O) (=O) =O.CS (O) (=O) =O.C\C (=N/N=C (N) N) c1ccc (NC (=O) Nc2ccc (cc2) C (\C) =N\N=C (N) N) cc1
Molecular Formula
C21H32N10O7S2
Molecular Weight
600.67
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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