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NSC 109555

NSC 109555 is a potent and selective ATP-competitive inhibitor of Chk2 (IC50 = 0.2 μM) with minimal activity against Chk1. It inhibits histone H1 phosphorylation and mitochondrial ATP synthesis, demonstrating antiproliferative effects in leukemia models both in vitro and in vivo.

Product Specifications

CAS Number

15427-93-7

Field of Research

Cell Biology, Neuroscience

Smiles

CS (O) (=O) =O.CS (O) (=O) =O.C\C (=N/N=C (N) N) c1ccc (NC (=O) Nc2ccc (cc2) C (\C) =N\N=C (N) N) cc1

Molecular Formula

C21H32N10O7S2

Molecular Weight

600.67

Storage Conditions

-20°C

Notes

For research use only.

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