NH2-Gly-PAB-Exatecan-D-glucuronic acid (formic)
Product Specifications
UNSPSC Description
NH2-Gly-PAB-Exatecan-D-glucuronic acid formic (Compound 8) is the formic salt form of H2N-Gly-PAB-Exatecan-D-glucuronic acid. H2N-Gly-PAB-Exatecan-D-glucuronic acid formic is an intermediate, which reacts with NHS group to form drug-linker conjugate for ADC, Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179)[1].
Target Antigen
ADC Cytotoxin
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nh2-gly-pab-exatecan-d-glucuronic-acid-formic.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NCC(NC(C=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=C(C=C1)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O.OC=O
Molecular Weight
879.79
References & Citations
[1]DICKGIESSER S, et al., Methods and tools for conjugation to antibodies. WO2023170239.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160885A/NH2-Gly-PAB-Exatecan-D-glucuronic-acid-formic-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160885A/NH2-Gly-PAB-Exatecan-D-glucuronic-acid-formic-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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