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NH2-Gly-PAB-Exatecan-D-glucuronic acid (formic)

Selected Variant

HY-160885A-01

Size: 5 mg

NH2-Gly-PAB-Exatecan-D-glucuronic acid formic (Compound 8) is the formic salt form of H2N-Gly-PAB-Exatecan-D-glucuronic acid. H2N-Gly-PAB-Exatecan-D-glucuronic acid formic is an intermediate, which reacts with NHS group to form drug-linker conjugate for ADC, Mal-Gly-PAB-Exatecan-D-glucuronic acid.

Product Specifications

UNSPSC

12352005

Target

ADC Payload

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nh2-gly-pab-exatecan-d-glucuronic-acid-formic.html

Concentration

10mM

Purity

99.34

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NCC(NC(C=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=C(C=C1)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O.OC=O

Molecular Formula

C41H42FN5O16

Molecular Weight

879.79

References & Citations

[1]DICKGIESSER S, et al., Methods and tools for conjugation to antibodies. WO2023170239.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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