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SKLB 1028

SKLB 1028 (Ruserontinib) is an oral multikinase inhibitor targeting EGFR, FLT3, and Abl kinases. It demonstrates potent efficacy in FLT3-driven acute myeloid leukemia (AML) models in vitro and in vivo, and shows significant activity against chronic myeloid leukemia (CML) models harboring Abl mutations.

Product Specifications

CAS Number

1350544-93-2

Product Name Alternative

BcrAbl, Abl, EGFR, FLT3, SKLB1028, SKLB-1028, SKLB 1028, Ruserontinib

Field of Research

Cardiovascular Research, Signal Transduction

Purity

99.71% (May vary between batches)

Solubility

DMSO:50 mg/mL (112.73 mM)

Smiles

C (C) (C) N1C=2C (N=C1NC=3C=CC=NC3) =CN=C (NC4=CC=C (C=C4) N5CCN (C) CC5) N2

Molecular Formula

C24H29N9

Molecular Weight

443.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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