TL12-186
TL12-186 is a cereblon-dependent PROTAC degrader targeting multiple kinases, including CDK2, CDK9, BTK, FLT3, and Aurora kinases. It potently inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50 values of 73 nM and 55 nM, respectively. This compound is a valuable research tool for investigating kinase function and degradation mechanisms in both cellular and in vivo models of cancer and other diseases.
Product Specifications
CAS Number
2250025-88-6
Product Name Alternative
CDK2/CyclinA, CDK9/cyclin T1, Cereblon, TL12 186, TL12186, TL-12186, TL12-186, TL 12186
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.20% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.37 mM) ; DMSO:200 mg/mL (214.72 mM)
Smiles
O=C1NC (=O) C (N2C (=O) C=3C=CC=C (NCC (=O) NCCOCCOCCN4CCN (C5=CC=C (C=C5) NC6=NC=C (Cl) C (=N6) NC=7C=CC=CC7S (=O) (=O) C (C) C) CC4) C3C2=O) CC1
Molecular Formula
C44H51ClN10O9S
Molecular Weight
931.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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