Liothyronine (Standard)

Liothyronine (Standard) is the analytical standard of Liothyronine. This product is intended for research and analytical applications. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

Product Specifications

CAS Number

[6893-02-3]

Product Name Alternative

Triiodothyronine (Standard) ; 3,3',5-Triiodo-L-thyronine (Standard) ; T3 (Standard)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; Reference Standards; Thyroid Hormone Receptor

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/liothyronine-standard.html

Purity

98.57

Solubility

10 mM in DMSO

Smiles

OC1=C(I)C=C(OC2=C(I)C=C(C[C@H](N)C(O)=O)C=C2I)C=C1

Molecular Formula

C15H12I3NO4

Molecular Weight

650.97

Precautions

H315, H319, H335

References & Citations

[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94.|[2]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20 (11) :3622-34.|[3]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195 (1) :385-92.