Compound E
γ-Secretase-IN-1 is a potent inhibitor of γ-secretase, effectively suppressing the cleavage of β-amyloid (40/42) and Notch. It demonstrates partial antiproliferative effects in T-47D cell cultures, making it a useful research tool for studying Alzheimer's disease pathways and Notch-related oncology in vitro.
Product Specifications
CAS Number
209986-17-4
Product Name Alternative
γ-Secretase Inhibitor XXI; Cpd E
Field of Research
Neuroscience, Stem Cell & Developmental Biology
Purity
>98%
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
C[C@H] (NC (=O) Cc1cc (F) cc (F) c1) C (=O) N[C@H]1N=C (c2ccccc2) c2ccccc2N (C) C1=O
Molecular Formula
C27H24F2N4O3
Molecular Weight
490.5
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[ (1S) -2-[[ (3S) -2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
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