5α-Hydroxy-6-keto cholesterol
5α-Hydroxy-6-keto cholesterol is a cytotoxic β-epoxide oxysterol generated from ozone-exposed human bronchial cells. It potently inhibits endogenous cholesterol synthesis with an IC50 of 350 nM. This metabolite serves as a valuable research tool for studying oxidative stress responses, lipid metabolism disruption, and cellular toxicity in pulmonary models.
Product Specifications
CAS Number
13027-33-3
Field of Research
Metabolism Research
Smiles
C[C@@]12[C@@]3 ([C@] ([C@]4 ([C@] (C) (CC3) [C@@] ([C@@H] (CCCC (C) C) C) (CC4) [H]) [H]) (CC (=O) [C@@]1 (O) C[C@@H] (O) CC2) [H]) [H]
Molecular Formula
C27H46O3
Molecular Weight
418.66
Storage Conditions
-20°C
Notes
For research use only.
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