LDN-193189 2HCl
LDN-193189 2HCl is a potent and selective BMP type I receptor (ALK1, ALK2, ALK3, ALK6) inhibitor, demonstrating low nanomolar IC50 values in kinase and cellular assays. It is over 200-fold selective for BMP over TGF-β signaling. This inhibitor is widely used in research to study bone morphogenetic protein pathways in both in vitro and in vivo models of osteogenesis, hematopoiesis, and fibrodysplasia ossificans progressiva.
Product Specifications
CAS Number
1435934-00-1
Product Name Alternative
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.78% (May vary between batches)
Solubility
H2O:45 mg/mL (93.87 mM) ; DMSO:8.77 mg/mL (18.29 mM)
Smiles
C1 (C2=C3N=CC (C4=CC=C (N5CCNCC5) C=C4) =CN3N=C2) =C6C=CC=CC6=NC=C1.Cl.Cl
Molecular Formula
C25H24Cl2N6
Molecular Weight
479.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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