(S) -p38 MAPK Inhibitor III

This cell-permeable methylsulfanylimidazole compound is a potent and selective p38 MAP kinase inhibitor, exhibiting an IC50 of 0.90 μM in enzymatic assays. It effectively suppresses pro-inflammatory cytokine release, specifically TNF-α and IL-1β, from human PBMCs with IC50 values of 0.37 μM and 0.044 μM, respectively, making it a valuable tool for inflammation and signal transduction research.