(E) -5- (2-Bromovinyl) uracil
(E) -5- (2-Bromovinyl) uracil (BVU) is a metabolite of antiviral nucleosides and a mechanism-based inactivator of dihydropyrimidine dehydrogenase (DPD) . Its irreversible inhibition of DPD enhances the antitumor activity of 5-fluorouracil, as demonstrated in murine leukemia models, making it a research tool for studying fluoropyrimidine pharmacology and combination chemotherapy strategies.
Product Specifications
CAS Number
69304-49-0
Field of Research
Cell Biology, Molecular Biology
Smiles
C (=C/Br) \C=1C (=O) NC (=O) NC1
Molecular Formula
C6H5BrN2O2
Molecular Weight
217.02
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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