(E) -5- (2-Bromovinyl) uracil

(E) -5- (2-Bromovinyl) uracil (BVU) is a metabolite of antiviral nucleosides and a mechanism-based inactivator of dihydropyrimidine dehydrogenase (DPD) . Its irreversible inhibition of DPD enhances the antitumor activity of 5-fluorouracil, as demonstrated in murine leukemia models, making it a research tool for studying fluoropyrimidine pharmacology and combination chemotherapy strategies.