YW1128
YW1128 is a potent small molecule inhibitor of the Wnt/β-catenin pathway, exhibiting an IC50 of 4.1 nM. It reduces β-catenin and elevates Axin1 protein levels in vitro. In vivo, it ameliorates diet-induced metabolic dysfunction, improving glucose tolerance and reducing hepatic steatosis in mouse models.
Product Specifications
CAS Number
2131223-64-6
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Smiles
CC=1N (N=NC1C (NC2=NC3=C (C=C2) C=CC=C3) =O) C4=C (C) C=CC=C4
Molecular Formula
C20H17N5O
Molecular Weight
343.38
Storage Conditions
-20°C
Notes
For research use only.
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