KAAD-Cyclopamine
Cyclopamine-KAAD is a potent, cell-permeable Smoothened (Smo) inhibitor that blocks hedgehog signaling with an IC50 of 20 nM. It inhibits cancer cell migration and invasion, modulates Gli1 and ERK signaling, and sensitizes glioma cells to TRAIL-induced apoptosis by upregulating death receptors DR4 and DR5. This compound is a valuable tool for studying hedgehog pathway mechanisms in oncology research.
Product Specifications
CAS Number
306387-90-6
Field of Research
Stem Cell & Developmental Biology
Smiles
C[C@H]1[C@]2 (C (C) =C3[C@@] (CC2) ([C@]4 ([C@] (C3) ([C@]5 (C) C (=CC4) CC (=O) CC5) [H]) [H]) [H]) O[C@]6 ([C@]1 (N (CCNC (CCCCCNC (CCC7=CC=CC=C7) =O) =O) C[C@@H] (C) C6) [H]) [H]
Molecular Formula
C44H63N3O4
Molecular Weight
697.99
Storage Conditions
-20°C
Notes
For research use only.
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