PF-5274857 hydrochloride
PF-5274857 hydrochloride is a potent, selective, and orally bioavailable Smoothened (Smo) antagonist with an IC50 of 5.8 nM, capable of crossing the blood-brain barrier. It is utilized in preclinical research to investigate Hedgehog pathway-driven malignancies, including primary brain tumors and metastatic brain cancers, in both cellular and animal models.
Product Specifications
CAS Number
1613439-62-5
Field of Research
Stem Cell & Developmental Biology
Smiles
Cl.Cc1cnc (c (C) c1) -c1cc (ncc1Cl) N1CCN (CC1) C (=O) CCS (C) (=O) =O
Molecular Formula
C20H26Cl2N4O3S
Molecular Weight
473.42
Storage Conditions
-20°C
Notes
For research use only.
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