PKSI-527
PKSI-527 is a potent and selective plasma kallikrein inhibitor (Ki = 0.81 μM) . It effectively reduces bradykinin generation in human plasma ex vivo and modulates coagulation parameters. This inhibitor is a valuable research tool for studying the kallikrein-kinin system in thrombosis, inflammation, and hereditary angioedema.
Product Specifications
CAS Number
128837-71-8
Field of Research
Protein Biochemistry
Purity
>97%
Bioactivity
Plasma kallikrein inhibitor (selective)
Form
Powder
Solubility
Soluble in Water (up to 5 mg/ml)
Smiles
[C@@H] (CC1=CC=CC=C1) (NC (=O) [C@H]2CC[C@H] (CN) CC2) C (NC3=CC=C (CC (O) =O) C=C3) =O.Cl
Molecular Formula
C25H31N3O4·HCl
Molecular Weight
474.0
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
Trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide, hydrochloride
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