CC-90005

CC-90005 is a potent, selective, and orally bioavailable inhibitor of protein kinase C-theta (PKC-θ), demonstrating an IC50 of 8 nM with significant selectivity over PKC-δ. It effectively suppresses T cell activation, as shown by the inhibition of IL-2 expression in vitro, making it a valuable tool for immunology and autoimmune disease research.