KRM-III
KRM-III is an orally bioavailable small molecule that suppresses T cell activation and proliferation by inhibiting TCR and PMA/ionomycin-induced NFAT signaling, with an IC50 of ~5 μM. It serves as a valuable research tool for studying T cell-mediated immune responses in both in vitro assays and in vivo inflammatory disease models.
Product Specifications
CAS Number
79220-94-3
Product Name Alternative
KRM III, KRMIII, KRM-III, Nuclear factor of activated Tcells (NFAT)
Purity
99.25% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.93 mM) ; DMSO:25.23 mg/mL (99.99 mM)
Smiles
S=c1[nH]c (cn1-c1ccccc1) -c1ccccc1
Molecular Formula
C15H12N2S
Molecular Weight
252.33
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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