AZ 5704
This orally bioavailable, highly potent and selective ATM kinase inhibitor (enzyme IC50 = 0.6 nM) demonstrates >600-fold selectivity and cellular activity (IC50 = 0.33 μM) . It is a valuable research tool for studying DNA damage response and has been shown to potentiate irinotecan's antitumor effects in vivo.
Product Specifications
CAS Number
1941214-06-7
Field of Research
Molecular Biology, Signal Transduction
Purity
99.69% (May vary between batches)
Smiles
N ([C@@H] (C) C1=NN (C) C=C1) C=2C3=C (C=C (F) C (=C3) C=4C=CC (COC) =NC4) N=CC2C (N) =O
Molecular Formula
C23H23FN6O2
Molecular Weight
434.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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