CAY10747
CAY10747 is a celastrol-derived inhibitor that disrupts the Hsp90-Cdc37 chaperone complex, leading to reduced client protein levels like p-Akt and Cdk4. It demonstrates anti-proliferative and pro-apoptotic activity in various cancer cell lines, including A549 and MCF-7 cells, supporting its use in oncology research for studying Hsp90-dependent signaling pathways.
Product Specifications
CAS Number
2413849-81-5
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Smiles
C[C@@]12[C@] (C) ([C@]3 ([C@@] (C) (CC1) CC[C@] (C (OCCCOC (/C=C (\C#N) /C4=CC=C (F) C=C4) =O) =O) (C) C3) [H]) CC[C@]5 (C) C2=CC=C6C5=CC (=O) C (O) =C6C
Molecular Formula
C42H48FNO6
Molecular Weight
681.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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