AZD 3147
AZD 3147 is a potent and selective mTORC inhibitor, demonstrating IC50 values of 5.75 nM for mTORC2 and 40.7 nM for mTORC1, with significantly lower activity against PI3K isoforms. This selectivity profile makes it a valuable chemical probe for studying mTOR signaling in cancer research and cellular biology, applicable in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1101810-02-9
Product Name Alternative
AZD3147, AZD-3147, AZD 3147, mTORC1, mTORC2
Field of Research
Signal Transduction
Purity
98.34% (May vary between batches)
Solubility
Hydrochloride acid:100 mg/mL (193.18 mM) ; Ethanol:1 mg/mL (1.93 mM) ; DMSO:46.8 mg/mL (90.41 mM)
Smiles
S (=O) (=O) (C1 (CC1) C=2C=C (N=C (N2) C3=CC=C (NC (NCCO) =S) C=C3) N4[C@@H] (C) COCC4) C5CC5
Molecular Formula
C24H31N5O4S2
Molecular Weight
517.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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