SJF 1521
SJF 1521 is a PROTAC-based small molecule that induces selective degradation of EGFR without affecting HER2. It serves as a valuable chemical probe for studying EGFR-dependent signaling and oncology research in both cellular and animal models.
Product Specifications
CAS Number
2230821-40-4
Product Name Alternative
EGFR, PROTAC, SJF 1521, SJF1521, SJF-1521
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.20% (May vary between batches)
Solubility
DMSO:80 mg/mL (74.44 mM)
Smiles
N (C=1C2=C (C=CC (=C2) C3=CC=C (OCCOCCOCCOCC (N[C@H] (C (=O) N4[C@H] (C (NCC5=CC=C (C=C5) C6=C (C) N=CS6) =O) C[C@@H] (O) C4) [C@] (C) (C) C) =O) C=C3) N=CN1) C7=CC (Cl) =C (OCC8=CC (F) =CC=C8) C=C7
Molecular Formula
C57H61ClFN7O9S
Molecular Weight
1074.65
Storage Conditions
-20°C
Notes
For research use only.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LS027159-20ug 20 µg
AMCase (CHIA) (NM_021797) Human Over-expression Lysate
Sign In for Pricing
View Details 
GTR15267253 1 Vial
Lentiviral mouse Ly9 shRNA (UAS) - Lentiviral mouse Ly9 shRNA (UAS, RFP) plasmid
Sign In for Pricing
View Details 
MBS1345137-01 0.02 mg (E-Coli)
Recombinant Pongo abelii BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)
Sign In for Pricing
View Details MBS1345137-02 0.02 mg (Yeast)
Recombinant Pongo abelii BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)
Sign In for Pricing
View Details MBS1345137-03 0.1 mg (E-Coli)
Recombinant Pongo abelii BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)
Sign In for Pricing
View Details MBS1345137-04 0.1 mg (Yeast)
Recombinant Pongo abelii BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)
Sign In for Pricing
View Details