LC-2
LC-2 is a VHL-based PROTAC that covalently engages endogenous KRAS G12C via MRTX849 to induce its targeted degradation (DC50 ~0.25-0.76 μM) and suppress MAPK signaling. This tool compound is used in vitro for oncology research, particularly in studying KRAS-driven cancers and targeted protein degradation.
Product Specifications
CAS Number
2502156-03-6
Product Name Alternative
LC 2, LC2, LC-2, PROTAC, PROTAC KRASG12C Degrader-LC-2
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:30 mg/mL (26.48 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.77 mM)
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) CCOCCCN2CCC[C@H]2COc2nc3CN (CCc3c (n2) N2CCN ([C@@H] (CC#N) C2) C (=O) C (F) =C) c2cccc3cccc (Cl) c23) C (C) (C) C) cc1
Molecular Formula
C59H71ClFN11O7S
Molecular Weight
1132.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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