Wortmannin-Rapamycin Conjugate
This bifunctional prodrug conjugate combines analogs of the PI3K inhibitor wortmannin and the mTORC1 inhibitor rapamycin. Upon linker hydrolysis in vivo, it demonstrates superior antitumor efficacy and tolerability in xenograft models, such as HT-29 and A498 tumors, and shows enhanced activity when combined with anti-angiogenic agents like bevacizumab.
Product Specifications
CAS Number
1067892-47-0
Field of Research
Signal Transduction
Smiles
[H][C@@]12CC[C@H] (OC (=O) CCCCCCC (=O) O[C@@H]3CC[C@@H] (C[C@@H] (C) [C@]4 ([H]) CC (=O) [C@H] (C) \C=C (C) /[C@@H] (O) [C@@H] (OC) C (=O) [C@H] (C) C[C@H] (C) \C=C/C=C\C=C (C) /[C@H] (C[C@]5 ([H]) CC[C@@H] (C) [C@@] (O) (O5) C (=O) C (=O) N5CCCC[C@@]5 ([H]) C (=O) O4) OC) C[C@H]3OC) [C@@]1 (C) C[C@@H] (OC (C) =O) C1=C2C (=O) C (O) =C2\C (=C/N (C) CCCN (C) C) C (=O) O[C@H] (COC) [C@]12C |c:46,48,97, t:31,50,103|
Molecular Formula
C88H131N3O23
Molecular Weight
1599.014
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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