C8 D-threo Ceramide (d18:1/8:0)

C8 D-threo Ceramide is a cell-permeable, cytotoxic ceramide analog that potently induces DNA fragmentation and activates ceramide-activated protein kinase (CAPK) in U937 cells. It serves as a substrate for E. coli diacylglycerol kinase and enhances pore formation by V. cholerae cytolysin in lipid membrane models, supporting research in sphingolipid signaling, apoptosis, and bacterial toxin mechanisms.