AAF-CMK (trifluoroacetate salt)
Tripeptidyl peptidase II (TPPII) is a subtilisin-type serine peptidase that cleaves tripeptides from oligopeptide N-termini. The irreversible inhibitor AAF-CMK (10-100 μM) selectively targets TPPII without affecting proteasomal chymotrypsin-like activity, though it also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase at 50 μM. This compound is a valuable tool for studying intracellular protein degradation pathways in both cellular and biochemical assays.
Product Specifications
CAS Number
184901-82-4
Field of Research
Protein Biochemistry
Smiles
OC (=O) C (F) (F) F.C[C@H] (N) C (=O) N[C@@H] (C) C (=O) N[C@H] (Cc1ccccc1) C (=O) CCl
Molecular Formula
C18H23ClF3N3O5
Molecular Weight
453.84
Storage Conditions
-20°C
Notes
For research use only.
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