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(R, R) -CXCR2-IN-2

(R, R) -CXCR2-IN-2 is a brain-penetrant CXCR2 antagonist, a diastereoisomer of compound 68. It demonstrates potent antagonistic activity with a pIC50 of 9.0 in the Tango assay and 6.8 in a human whole blood CD11b expression assay. This compound is a valuable research tool for investigating CXCR2-mediated neuroinflammation in both in vitro and in vivo models.

Product Specifications

CAS Number

1838123-22-0

Field of Research

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Smiles

CC1=CCC[C@H]1NC (=O) Nc1ccc (Cl) c (c1O) S (=O) (=O) [C@]1 (C) CCOC1

Molecular Formula

C18H23ClN2O5S

Molecular Weight

414.9

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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