CMLD-2
CMLD-2 is a potent, cell-permeable inhibitor of the HuR-ARE interaction (Ki: 350 nM) . It disrupts HuR's mRNA-stabilizing function, leading to downregulation of oncogenic targets like MAD2, which induces apoptosis, cell cycle arrest, and inhibits proliferation and migration in various cancer cell lines in vitro.
Product Specifications
CAS Number
958843-91-9
Product Name Alternative
CMLD 2, CMLD2, CMLD-2, Apoptosis
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
99.16% (May vary between batches)
Solubility
DMSO:65 mg/mL (126.56 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.89 mM)
Smiles
COc1ccc (cc1) C (CC (=O) N1CCCC1) c1c (OC) cc (OC) c2c (cc (=O) oc12) -c1ccccc1
Molecular Formula
C31H31NO6
Molecular Weight
513.58
Storage Conditions
-20°C
Notes
For research use only.
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