NO-Indomethacin
NO-indomethacin is a nitric oxide-donating hybrid of indomethacin designed to retain anti-inflammatory and analgesic efficacy while mitigating the gastrointestinal and renal toxicity associated with conventional NSAIDs. It demonstrates significantly enhanced potency in vitro, such as inhibiting pancreatic cancer cell (PaCa-2) growth with an IC50 of 82 μM, and shows promise for chemoprevention research.
Product Specifications
CAS Number
301838-28-8
Field of Research
Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery
Smiles
COc1ccc2n (C (=O) c3ccc (Cl) cc3) c (C) c (CC (=O) SC[C@@H] (NC (C) =O) C (=O) OCCCCON (=O) =O) c2c1
Molecular Formula
C28H30ClN3O9S
Molecular Weight
620.07
Storage Conditions
-20°C
Notes
For research use only.
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