Tie2 Inhibitor 7
Tie2 Inhibitor 7 is a potent small molecule antagonist of the Tie2 receptor tyrosine kinase, exhibiting a Ki of 1.3 μM and an IC50 of 0.3 μM against Ang1-induced autophosphorylation. It effectively blocks downstream signaling, inhibiting endothelial tube formation in vitro and choroidal neovascularization in vivo rat models, making it a valuable research tool for angiogenesis studies.
Product Specifications
CAS Number
1020412-97-8
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (O) (=O) C1=CC (C2=CC=C (CN (C (OC3=CC=C (C) C=C3) =O) CC (N[C@@H] (C) C4CCCCC4) =O) C=C2) =CN=C1
Molecular Formula
C31H35N3O5
Molecular Weight
529.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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