Dolutegravir O-β-D-Glucuronide
Dolutegravir O-β-D-glucuronide is the primary glucuronide metabolite of the antiretroviral drug dolutegravir. It is formed in vivo mainly via UGT1A1, with UGT1A9 and UGT1A3 also contributing in hepatic/kidney and intestinal tissues, respectively. This metabolite is a key reference standard for studying dolutegravir's pharmacokinetics, metabolism, and drug-drug interaction potential in both in vitro and in vivo research models.
Product Specifications
CAS Number
1485692-21-4
Field of Research
Pharmacology & Drug Discovery
Smiles
[H][C@]12Cn3cc (C (=O) NCc4ccc (F) cc4F) c (=O) c (O[C@@H]4O[C@@H] ([C@@H] (O) [C@H] (O) [C@H]4O) C (O) =O) c3C (=O) N1[C@H] (C) CCO2
Molecular Formula
C26H27F2N3O11
Molecular Weight
595.509
Storage Conditions
-20°C
Notes
For research use only.
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