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MRIA9

MRIA9 is a potent ATP-competitive inhibitor of pan-Salt-Inducible Kinases (SIK1/2/3) and PAK2/3. It demonstrates potent activity in vitro with IC50 values of 516 nM, 180 nM, and 127 nM against SIK1, SIK2, and SIK3, respectively. This tool compound is valuable for probing SIK signaling in cellular and in vivo models of immunology and cancer.

Product Specifications

CAS Number

2750707-05-0

Field of Research

Cell Biology, Signal Transduction

Smiles

C (N1C=2C (C=C (C1=O) C3=C (Cl) C=C (C=C3) C4=C (F) C=CC=N4) =CN=C (NC) N2) [C@@H]5OC[C@@H] (N) CO5

Molecular Formula

C24H22ClFN6O3

Molecular Weight

496.92

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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