S65487
S65487 (VOB560) is a potent and selective Bcl-2 inhibitor active against wild-type and mutant forms (e.g., G101V, D103Y) . Its high selectivity over MCL-1, BFL-1, and BCL-XL underpins its utility in apoptosis research, demonstrating robust anticancer activity in both cellular assays and in vivo preclinical models.
Product Specifications
CAS Number
1644600-79-2
Product Name Alternative
S 65487, S65487, S-65487, VOB 560, VOB560
Field of Research
Cell Biology
Purity
99.03% (May vary between batches)
Solubility
DMSO:160 mg/mL (223.07 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.97 mM)
Smiles
N (C (=O) C=1C=C (N (C) C1C) C2=C (C (=O) N3[C@H] (CN4CCOCC4) CC=5C (C3) =CC=CC5) C=CC (Cl) =C2) (C=6C=C (C#N) N (C) C6C) C7=CC=C (O) C=C7
Molecular Formula
C41H41ClN6O4
Molecular Weight
717.26
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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