INCB086550
INCB086550 (PD-1/PD-L1-IN-8) is a potent small-molecule inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of ≤10 nM. It is a valuable research tool for investigating immune checkpoint blockade in both in vitro cellular assays and in vivo preclinical cancer models.
Product Specifications
CAS Number
2230911-59-6
Product Name Alternative
INCB 086550, INCB086550, INCB-086550, PD-1/PD-L1-IN-8, PD-1/PD-L1, PD1/PDL1, PD-1, PD1, PDL1, PD-L1
Field of Research
Cell Biology, Immunology & Inflammation
Purity
98.21% (May vary between batches)
Solubility
DMSO:145 mg/mL (209 mM) ; H2O:75.6 mg/mL (108.97 mM)
Smiles
Cc1c (Nc2nccc3cc (CN4CC[C@@H] (O) C4) cnc23) cccc1-c1cccc (-c2nc3cc (CN4CC[C@H] (C4) C (O) =O) cc (C#N) c3o2) c1C
Molecular Formula
C41H39N7O4
Molecular Weight
693.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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