CXCR2-IN-2

CXCR2-IN-2 is a potent, selective, and brain-penetrant CXCR2 antagonist with oral bioavailability. It demonstrates high selectivity over CXCR1 and other chemokine receptors and effectively inhibits Gro-α-induced CD11b expression in human whole blood. This compound is a valuable tool for researching CXCR2's role in neuroinflammation, COPD, and cancer in both in vitro and in vivo models.