GSK 591 dihydrochloride
This compound is a potent and selective PRMT5 inhibitor with an IC50 of 4 nM, demonstrating anti-proliferative activity in mantle cell lymphoma models. It is a valuable chemical probe for investigating PRMT5 biology in cancer research, including studies of splicing regulation and cellular differentiation.
Product Specifications
CAS Number
2320953-89-5
Field of Research
Epigenetics & Chromatin
Smiles
Cl.Cl.O[C@@H] (CNC (=O) c1ccnc (NC2CCC2) c1) CN1CCc2ccccc2C1
Molecular Formula
C22H30Cl2N4O2
Molecular Weight
453.41
Storage Conditions
-20°C
Notes
For research use only.
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