Coixenolide

Coixenolide can be isolated from coix seeds, and exhibits anti-inflammatory, anti-tumor and pain-reducing activities. Coixenolide stimulates the lung, heart, striated and smooth muscles at low doses, while inhibits at high doses. Coixenolide dilates pulmonary veins and improves pulmonary blood circulation. Coixenolide can also be used as nutraceuticals and functional foods. Coixenolide enhances the prodcutionof mycelia biomass and polysaccharides when added to the media of submerged culture of G. lucidum. Coixenolide affects the synthesis level of phosphoglucose isomerase and α-phosphoglucomutase[1][2].

Product Specifications

CAS Number

[29066-43-1]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/coixenolide.html

Purity

99.93

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : ≥ 100 mg/mL|THF : 40 mg/mL (ultrasonic)

Smiles

CCCCCC/C=C\CCCCCCCC(O[C@H](C)[C@H](C)OC(CCCCCCCCC/C=C/CCCCCC)=O)=O

Molecular Formula

C38H70O4

Molecular Weight

590.96

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hu AJ, et al., Ultrasound assisted supercritical fluid extraction of oil and coixenolide from adlay seed. Ultrason Sonochem. 2007 Feb;14 (2) :219-24.|[2]Zhou, H., et al., (2014) . Improved polysaccharide production in submerged culture of Ganoderma lucidum by the addition of coixenolide. Applied biochemistry and biotechnology, 172 (3), 1497–1505.