Glucagon Receptor Antagonist I
This compound is a competitive glucagon receptor (GCGR) antagonist with an IC50 of 181 nM. It effectively inhibits glucagon-stimulated glycogenolysis in human hepatocytes and, in vivo, attenuates glucagon-induced hyperglycemia in mice at 50 mg/kg, making it a valuable tool for studying hepatic glucose metabolism and diabetes.
Product Specifications
CAS Number
438618-32-7
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
C (#N) C=1C2=C (SC1NC (C (CC) CC) =O) CC (C (CC) (C) C) CC2
Molecular Formula
C20H30N2OS
Molecular Weight
346.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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