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Glucagon Receptor Antagonist I

This compound is a competitive glucagon receptor (GCGR) antagonist with an IC50 of 181 nM. It effectively inhibits glucagon-stimulated glycogenolysis in human hepatocytes and, in vivo, attenuates glucagon-induced hyperglycemia in mice at 50 mg/kg, making it a valuable tool for studying hepatic glucose metabolism and diabetes.

Product Specifications

CAS Number

438618-32-7

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Smiles

C (#N) C=1C2=C (SC1NC (C (CC) CC) =O) CC (C (CC) (C) C) CC2

Molecular Formula

C20H30N2OS

Molecular Weight

346.53

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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