Cyclophilin inhibitor 1

Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a Kd of 5 nM, shows effective anti-HCV activity, with an EC50 of 98 nM for HCV 2a[1].

Product Specifications

CAS Number

[1509904-96-4]

UNSPSC

12352005

Target

Cyclophilin; HCV

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Cyclophilin_inhibitor_1.html

Purity

99.55

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@@H](NC([C@@H]1CCCN(C([C@H](C)NC([C@H](C(C)C)OC2=O)=O)=O)N1)=O)C3=CC=C4C(C=C(/C=C/C52COCOC5)C=C4)=N3

Molecular Formula

C31H39N5O7

Molecular Weight

593.67

References & Citations

[1]Mackman RL, et al. Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle. J Med Chem. 2018 Nov 8;61 (21) :9473-9499.