PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1 is a novel small molecule that induces the ubiquitin-proteasome degradation of IDO1 via CRBN E3 ligase recruitment (DC50 = 2.84 μM) . This degradation mechanism can be applied in cancer immunotherapy research, as it has been shown to enhance the antitumor activity of HER2-targeted CAR-T cells in vitro.
Product Specifications
CAS Number
2488851-89-2
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
O\N=C (/Nc1ccc (F) c (Br) c1) c1nonc1NCCNCCOCCOCCOCCOCCOCCOCCOCCNc1cccc2C (=O) N (C3CCC (=O) NC3=O) C (=O) c12
Molecular Formula
C40H53BrFN9O13
Molecular Weight
966.816
Storage Conditions
-20°C
Notes
For research use only.
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