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SR 12460

SR 12460 is a small molecule that acts as an NBD mimetic, disrupting the IKKβ/NEMO interaction to inhibit NF-κB activation triggered by TNF-α or LPS. It has demonstrated efficacy in cellular assays and reduces acute pulmonary inflammation in mouse models, making it a useful research tool for studying inflammatory signaling pathways.

Product Specifications

CAS Number

2055101-66-9

Smiles

O=C (NC1=NC=C (Cl) C=C1) CNCCC=2C=C (F) C=C (F) C2

Molecular Formula

C15H14ClF2N3O

Molecular Weight

325.74

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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