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BIRT-377

BIRT-377 is a potent, orally bioavailable negative allosteric inhibitor of the ICAM-1/LFA-1 interaction (Ki = 25.8 nM) . It suppresses IL-2 production and is utilized in research models of inflammatory and autoimmune diseases, including in vitro adhesion assays and in vivo studies of immune cell recruitment.

Product Specifications

CAS Number

213211-10-0

Product Name Alternative

BIRT 377, BIRT377, BIRT-377, ICAM-1, IL Receptor, IL-2, ILReceptor, LFA-1

Field of Research

Immunology & Inflammation, Signal Transduction

Purity

99.93% (May vary between batches)

Solubility

DMSO:90 mg/mL (203.56 mM)

Smiles

CN1C (=O) N (C (=O) [C@@]1 (C) Cc1ccc (Br) cc1) c1cc (Cl) cc (Cl) c1

Molecular Formula

C18H15BrCl2N2O2

Molecular Weight

442.13

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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