BIRT-377
BIRT-377 is a potent, orally bioavailable negative allosteric inhibitor of the ICAM-1/LFA-1 interaction (Ki = 25.8 nM) . It suppresses IL-2 production and is utilized in research models of inflammatory and autoimmune diseases, including in vitro adhesion assays and in vivo studies of immune cell recruitment.
Product Specifications
CAS Number
213211-10-0
Product Name Alternative
BIRT 377, BIRT377, BIRT-377, ICAM-1, IL Receptor, IL-2, ILReceptor, LFA-1
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
99.93% (May vary between batches)
Solubility
DMSO:90 mg/mL (203.56 mM)
Smiles
CN1C (=O) N (C (=O) [C@@]1 (C) Cc1ccc (Br) cc1) c1cc (Cl) cc (Cl) c1
Molecular Formula
C18H15BrCl2N2O2
Molecular Weight
442.13
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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