VEGFR-IN-1

VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively[1].

Product Specifications

CAS Number

[269390-69-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

C-Kit; EGFR; VEGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-in-1.html

Purity

99.07

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(Cl)C=C1)C2=CC=CC=C2NCC3=CC=NC=C3

Molecular Formula

C19H16ClN3O

Molecular Weight

337.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Furet P, et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett. 2003;13 (18) :2967-2971.