ONO-RS-082

ONO-RS-082 is an inhibitor of phospholipase A (PLA) [1]. ONO-RS-082 inhibits PLA2 with the IC50 of 1.0 μM, but does not inhibit PLC even at 100 μM[2].

Product Specifications

CAS Number

[99754-06-0]

UNSPSC

12352005

Hazard Statement

H400, H410

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ono-rs-082.html

Purity

99.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC(NC(/C=C/C2=CC=C(C=C2)CCCCC)=O)=C(C=C1)C(O)=O

Molecular Formula

C21H22ClNO3

Molecular Weight

371.86

Precautions

H400, H410

References & Citations

[1]H S Banga, et al. Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine. Proc Natl Acad Sci U S A.1986 Dec;83 (23) :9197-201.|[2]H Ohno, et al. Effect of phospholipase A2 inhibitors on mouse T lymphocytes. I. Phospholipase A2 inhibitors exert similar immunological activities as glycosylation inhibiting factor. Int Immunol. 1989;1 (4) :425-33.|[3]Bryan P Hurley, et al. Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300 (2) :L286-94.|[4]Hélène Le Ribeuz, et al. Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension. Biomolecules. 2020 Sep 1;10 (9) :1261.